Pet Recall Facts

Ingredients / Protamine Zinc Recombinant Human Insulin

Protamine Zinc Recombinant Human Insulin: FDA adverse event reports for pets

Reports received through June 26, 2026. Data and limitations.

1,920Total reports
237Dog reports
875Cat reports

FDA-approved products with this ingredient (Green Book)

All approved products with this ingredient, for any species.

Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).

Reports by year received

201218
20131
201750
2018124
2019292
2020265
2021263
2022201
2023168
2024255
2025186
202697

Species named in reports

Cat875
Not given801
Dog237
Human7

Signs reported after Protamine Zinc Recombinant Human Insulin

Containers, Damaged402
INEFFECTIVE, GLYCEMIC CONTROL390
Lack of efficacy - NOS356
Vials, Damaged244
Hypoglycaemia178
Appearance, Abnormal87
Lethargy (see also Central nervous system depression in Neurological)81
Death by euthanasia76
Vomiting72
INEFFECTIVE, LOSS OF EFFECT68
Product Defect, General67
Seal, Abnormal52
Vials, Leaking35
Diarrhoea32
Closure, Missing31
Anorexia30
Seizure NOS27
Suspension, Abnormal26
Weight loss26
Solution/Suspension, crystals25
Death25
Not eating23
Incorrect storage of drug22
Elevated blood urea nitrogen (BUN)21
Precipitate, Sediment20

Breeds named in reports

Domestic Shorthair507
Cat (unknown)175
Domestic Longhair71
Domestic Mediumhair33
Siamese29
Dog (unknown)23
Retriever - Labrador20
Terrier - Yorkshire18
Crossbred Canine/dog16
Maine Coon15
Schnauzer - Miniature15
Shih Tzu14
Chihuahua14
Maltese10
Terrier (unspecified)9

Reported outcomes

Outcome Unknown774
Recovered/Normal179
Euthanized76
Ongoing66
Died26

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